Idrossicarbamide [Dcit]

Idrossicarbamide [Dcit] Brand names, Idrossicarbamide [Dcit] Analogs

Idrossicarbamide [Dcit] Brand Names Mixture

No information avaliable

Idrossicarbamide [Dcit] Chemical_Formula

CH₄N₂O₂

Idrossicarbamide [Dcit] RX_link

http://www.rxlist.com/cgi/generic2/hydroxyurea.htm

Idrossicarbamide [Dcit] fda sheet

Idrossicarbamide_[Dcit] FDA

Idrossicarbamide [Dcit] msds (material safety sheet)

Idrossicarbamide_[Dcit] MSDS

Idrossicarbamide [Dcit] Synthesis Reference

No information avaliable

Idrossicarbamide [Dcit] Molecular Weight

76.0547 g/mol

Idrossicarbamide [Dcit] Melting Point

142-146 ^oC

Idrossicarbamide [Dcit] H₂O Solubility

1E+006 mg/L

Idrossicarbamide [Dcit] State

Solid

Idrossicarbamide [Dcit] LogP

-1.432

Idrossicarbamide [Dcit] Dosage Forms

Capsule

Idrossicarbamide [Dcit] Indication

For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.

Idrossicarbamide [Dcit] Pharmacology

Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.

Idrossicarbamide [Dcit] Absorption

Well absorbed from the gastrointestinal tract.

Idrossicarbamide [Dcit] side effects and Toxicity

Oral, mouse: LD₅₀ = 7330 mg/kg; Oral, rat: LD₅₀ = 5760 mg/kg

Idrossicarbamide [Dcit] Patient Information

HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children and pets.

Idrossicarbamide [Dcit] Organisms Affected

Humans and other mammals